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Effects of AMPA receptor modulators on synaptic transmission and long-term potentiation (LTP)

Gerhard Rammes

Effects of AMPA receptor modulators on synaptic transmission and long-term potentiation (LTP)

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Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D) - University of Birmingham, Department of Pharmacology, Faculty of Medicine and Dentistry, 1996.

Statementby Gerhard Rammes.
ID Numbers
Open LibraryOL17322203M


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Effects of AMPA receptor modulators on synaptic transmission and long-term potentiation (LTP) by Gerhard Rammes Download PDF EPUB FB2

AMPA Receptor Interacting Proteins. As mentioned above, subunit composition of AMPARs determine the routes of AMPAR trafficking, such that GluA1 is dominant over GluA2 during activity-dependent AMPAR exocytosis, while GluA2 is the primary determinant during endocytosis and post-endocytic endosomal sorting [].This differential regulation is mainly due to interactions of intracellular C-terminal Cited by: Positive alpha-aminohydroxymethylisoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus.

J Pharmacol Effects of AMPA receptor modulators on synaptic transmission and long-term potentiation book Ther ;–Author: Gary Lynch, Christine M. Gall. Blockade of adenosine A 2 receptors has been shown to significantly reduce the level of tetanus-induced long-term potentiation in area CA1 of rat hippocampus [Kessey K.

et al. () Brain Res, –; Sekino Y. et al. () Biochem. Commun, –]. In the present study, the effects of A 2 receptor activation and blockade on the modulation of normal synaptic Cited by: Introduction.

The induction of long-term potentiation (LTP) and long-term depression (LTD) of excitatory CA1 hippocampal synapses has been attributed at least in part to mechanisms that alter the contribution of postsynaptic AMPA receptors to excitatory transmission (2, 21, 33).Both LTP and LTD require the influx of Ca 2+ through postsynaptic NMDA receptors, although it is unclear how this Ca Cited by: Start studying Long Term Potentiation.

Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. AMPA receptor-glutamate ion channel, Na+ comes in, more Na+ channels or more glutamate release--both cases greater EPSP on postsynaptic cell Synaptic Transmission.

Janu March 5, Jooyeun Lee 13 Comments AMPA, Ca2+, Calcium, Cascade, Learning, Long-term potentiation, LTP, Memory, NMDA, Plasticity, Second messenger, Synapse, synaptic plasticity A few months ago, I got a new smart phone that had a bigger screen and a different operating system.

long-term potentiation in the ACC can be found in in vivo anesthetized rats. Peripheral injury produces long lasting enhancement of sensory synaptic res-ponse to peripheral stimulation or local ACC stimula-tion (Wei et al., ; Wu et al., b), suggesting that excitatory synaptic transmission within the ACC.

The α-aminohydroxymethylisoxozolepropionic acid (AMPA) receptor-mediated basal synaptic responses in the CA1 region of mutant mice were smaller than those of wild-type mice, while there wasno difference in N-methyl-d-aspartate receptor-mediated responses, suggesting selective postsynaptic modification of AMPA receptors by RyR3.

The. When the same NMDA blocking drugs that inhibit long term potentiation from being established are administered after the long term potentiation has been formed, they have no effect on the phenomenon. On the other hand, research indicates that another type of glutamate receptor, AMPA, does play an important role in sustained long term potentiation.

The potentiation of AMPA-receptor mediated synaptic transmission by allosteric positive modulators of this receptor (Ampakines™) may have beneficial behavioural effects in these diseases. Bidirectional changes in the efficacy of neuronal synaptic transmission, such as hippocampal long-term potentiation (LTP) and long-term depression (LTD), are thought to be mechanisms for.

AMPA receptors mediate the majority of excitatory glutamatergic transmission in the mammalian brain and are heterotetramers composed of GluA subunits. Despite genetic studies, the roles of the subunits in synaptic transmission and plasticity remain controversial.

To address this issue, we investigated the effects of cell-specific removal of GluA1 in hippocampal CA1 pyramidal neurons using.

The effects of a benzoyl-piperidine drug (BDP) that facilitates AMPA receptor-mediated synaptic responses were tested on the acquisition and retention of long-term memory at dosages that had no. By definition, positive allosteric modulators do not affect AMPA receptor activity alone but can markedly enhance ion flux through the ion channel pore in the presence of bound agonist.

Despite this commonality, positive allosteric modulators can be segregated on the basis of the preferential effects on AMPA receptor subunits, their Cited by: 1. Activity-dependent alteration in synaptic strength is a fundamental property of the vertebrate central nervous system and is thought to underlie learning and Cited by: 2.

Glutamate binds to NMDA receptor on post-synaptic neuron 3. Post-synaptic neuron triggers release of nitric oxide 4. Nitric oxide is a secondary neurotransmitter that triggers release of more glutamate from the presynaptic neuron. Glutamate synpases are surrounded by glia.

AMPA and NMDA receptors mediate most excitatory synaptic transmission in the CNS. We have developed antibodies that recognize all AMPA or all NMDA receptor variants on the surface of living neurons. AMPA receptor variants were identified with a polyclonal antibody recognizing the conserved extracellular loop region of all four AMPA receptor.

In conclusion, several potent, selective and systemically active AMPA receptor potentiators have been reported. Data indicate that these molecules modulate glutamatergic transmission, enhance synaptic transmission, long-term potentiation (LTP) and increase neurotrophin expression.

title = "Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA- preferring glutamate receptors", abstract = "Several studies have suggested that the function of glutamate receptor channels can be regulated by protein by: Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse.

In this review, we will provide an overview of NMDA receptor structure and function, followed by a review of the mechanism of action, clinical efficacy, and side effect profile of NMDA receptor ligands that are currently in Cited by: Positive allosteric modulators (PAMs) of α-aminohydroxymethylisoxazolepropionic acid (AMPA) receptors are a diverse class of compounds that increase fast excitatory transmission in the brain.

AMPA PAMs have been shown to facilitate long-term potentiation, strengthen communication between various cortical and subcortical regions, and some of these compounds increase the production and Cited by: 4. Thus, taken together with tCaMKII expression data, NTD-dependent interactions are essential for AMPA receptor anchoring, which is a prerequisite for synaptic potentiation.

Discussion AMPAR insertion into synapses has emerged as a central mechanism underlying the expression of LTP (Durand et al., ; Isaac et al., ; Liao et al., ).Cited by: Enter search terms. Keep search filters New search. Advanced search. The greater occurrence of silent synapses might be related to the greater magnitude of potentiation after long-term potentiation induction observed in these mice.

Together, these results suggest a synapse-specific role for PSD in controlling synaptic function that is independent of spine morphology. The superiority of spaced vs.

massed training is a fundamental feature of learning. Here, we describe unanticipated timing rules for the production of long-term potentiation (LTP) in adult rat hippocampal slices that can account for one temporal segment of the spaced trials phenomenon.

Successive bouts of naturalistic theta burst stimulation of field CA1 afferents markedly enhanced Cited by: Long-term depression (LTD) is a phenomenon that is the opposite of long-term potentiation (LTP).In LTD, communication across the synapse is silenced. LTD plays an important role in the cerebellum, in implicit procedural memory, where the neural networks involved in erroneous movements are inhibited by the silencing of their synaptic connections.

(7). Long Term Potentiation is defined as an increase in the strength of synaptic connections. This potentiation can be experimentally induced with a tetanus or through pairing (which is simultaneous stimulation of a neuron and depolarization of the postsynaptic neuron) (1).

At the postsynaptic face of the synapse, there are many. strength: AMPA receptors effect short-term changes in synaptic strength, whereas NMDA receptors regulate genes that are required for the long-term maintenance of these changes. Here, we review recent data on the roles of these two types of receptor in activity-dependent gene Cited by: Which leads to long-term potentiation.

And the development of working memory and long-term memory. But AMPA receptors do not work solo. Another glutamate receptor called NMDA receptors actually trigger the induction of long-term potentiation.

But these receptors are normally blocked by magnesium at resting membrane potentials. The insertion of AMPA receptors (AMPARs) into the plasma membrane is an important step in the synaptic delivery of AMPARs during the expression of synaptic plasticity.

Finally, disrupting N-dependent GluR1 insertion decreased surface expression of GluR1 and the expression of long-term potentiation.

Our study uncovers a previously unknown Cited by: In neuroscience, long-term potentiation (LTP) is the long-lasting strengthening of the connection between two nerve mentally, a series of short, high-frequency electric stimulations to a nerve cell synapse can strengthen, or potentiate, that synapse for minutes to living cells, LTP occurs naturally and can last from hours to days, months, and years.

Long-term synaptic plasticity is a generic term that applies to a long-lasting experience-dependent change in the efficacy of synaptic transmission. Here we will focus on N -methyl- d -aspartate (NMDA) receptor–dependent synaptic potentiation (LTP) and depression (LTD), two forms of activity-dependent long-term changes in synaptic efficacy.

Synaptic AMPA Receptor Insertion during LTP Figure 2. Selective Activation of Synaptic NMDA Receptors Induced LTP of mEPSCs AMPA in Cultured Hippocampal Neurons (A) LTP was blocked by coapplying the competitive antagonist AP5 (25 mM) together with glycine ( mM).

Peer-reviewed journal articles Han, Y., Chen, L.Y., Sudhof, T.C., and Zhang, B. Neuroligins Maintain Clustering of AMPA receptors at a central synapse. In revision. Incorporation during Long-Term Potentiation and Experience-Driven Synaptic Plasticity Ingrid Ehrlich and Roberto Malinow Cold Spring Harbor Laboratory, Cold Spring Harbor, New York The regulated delivery of AMPA-type glutamate receptors (AMPARs) to synapses is an important mechanism underlying synaptic plasticity.

Fast neuron-glia synaptic transmission has been found between hippocampal neurons and NG2 cells, a distinct population of macroglia-like cells widely distributed in the brain. We report that these neuron-glia synapses undergo activity-dependent modifications analogous to long-term potentiation (LTP) at excitatory synapses.

Nature Neuroscience, ISSN05/, Vol Issue 5, pp. -   Introduction. AMPA-type glutamate receptors (AMPARs) initiate postsynaptic signaling at excitatory synapses (Traynelis et al., ; Trussell, ).Receptor desensitization can shape synaptic transmission and in turn information processing (Chen et al., ; Koike-Tani et al., ; Rozov et al., ; Xu-Friedman and Regehr, ) as a function of the cleft glutamate transient (Cathala et.

Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron. ; – Otani S, Abraham WC. Inhibition of protein synthesis in the dentate gyrus, but not the entorhinal cortex, blocks maintenance of long-term potentiation in rats. Neurosci Lett. ; – The complementary process of long-term depression (LTD), in which the efficacy of synaptic transmission is reduced, shares these characteristics and has also received much attention as a candidate mnemonic process.

3,4 Whether LTP and LTD are the actual synaptic processes underlying learning and memory, as most neuroscientists believe, has not.

The capacity of synaptic networks to express activity-dependent changes in strength and connectivity is essential for learning and memory processes. In recent years, glial cells (most notably astrocytes) have been recognized as active participants in the modulation of synaptic transmission and synaptic plasticity, implicating these electrically nonexcitable cells in information processing in Cited by: 7.

The complementary process of long-term depression (LTD), in which the efficacy of synaptic transmission is reduced, shares these characteristics and has also received much attention as a candidate mnemonic process.

3, 4 Whether LTP and LTD are the actual synaptic processes underlying learning and memory, as most neuroscientists believe, has not.Slow Synaptic Responses and Modulation by K. Kuba,available at Book Depository with free delivery worldwide.